Rare diseases · Sign or symptom
Autoimmunity
Autoimmune disease
HP:0002960
What it means
The occurrence of an immune reaction against the organism's own cells or tissues.
In everyday care
Most people with this sign do not have a rare disease — it appears in common conditions far more often. These general reference pages cover the same topic:
Rare diseases that can present with this118
Very common80–99%
37- Acute adrenal insufficiency
- Addison disease
- Anti-glomerular basement membrane disease
- Antisynthetase syndrome
- Autoimmune hemolytic anemia, warm type
- Autoimmune lymphoproliferative syndrome
- Autoimmune polyendocrinopathy type 1
- Bullous pemphigoid
- Cold agglutinin disease
- Combined immunodeficiency due to CRAC channel dysfunction
- Dermatitis herpetiformis
- Dermatomyositis
- Diffuse cutaneous systemic sclerosis
- Eosinophilic granulomatosis with polyangiitis
- Felty syndrome
- Granulomatosis with polyangiitis
- IgG4-related submandibular gland disease
- Immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome
- Inclusion body myositis
- Insulin-resistance syndrome type B
- Juvenile dermatomyositis
- Late-onset isolated ACTH deficiency
- Limited cutaneous systemic sclerosis
- Linear IgA dermatosis
- Macrophage activation syndrome
- Microscopic polyangiitis
- Mixed connective tissue disease
- Mixed-type autoimmune hemolytic anemia
- Mucous membrane pemphigoid
- Pediatric-onset Graves disease
- Pemphigus erythematosus
- Pemphigus foliaceus
- Pemphigus vulgaris
- PGM3-CDG
- Polymyositis
- Primary sclerosing cholangitis
- Systemic-onset juvenile idiopathic arthritis
Common30–79%
31- Acquired generalized lipodystrophy
- Acquired partial lipodystrophy
- Activated PI3K-delta syndrome
- Activated PI3K-delta syndrome 1
- Aicardi-Goutières syndrome
- Autoimmune hemolytic anemia-autoimmune thrombocytopenia-primary immunodeficiency syndrome due to TPP2 deficiency
- Diffuse alveolar hemorrhage
- Encephalitis lethargica
- Focal stiff limb syndrome
- Hypocomplementemic urticarial vasculitis
- Idiopathic chronic eosinophilic pneumonia
- IgG4-related aortitis
- Insulin autoimmune syndrome
- Interstitial cystitis
- Livedoid vasculopathy
- Lymphoid interstitial pneumonia
- New-onset refractory status epilepticus
- Oligoarticular juvenile idiopathic arthritis
- Overlap myositis
- Primary biliary cholangitis
- Psoriasis-related juvenile idiopathic arthritis
- Purine nucleoside phosphorylase deficiency
- Rasmussen syndrome
- Recurrent infections associated with rare immunoglobulin isotypes deficiency
- Secondary non-traumatic avascular necrosis
- Selective IgM deficiency
- Spondyloenchondrodysplasia
- Syndromic multisystem autoimmune disease due to Itch deficiency
- T-B-NK- severe combined immunodeficiency due to adenosine deaminase deficiency
- T-cell immunodeficiency with thymic aplasia
- Wiskott-Aldrich syndrome
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions, and Orphanet separately records 9 diseases where this sign is specifically absent. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Autoimmune condition · Autoimmune disorder
Tracking symptoms like this for someone? Eleplan keeps symptoms, diagnoses, medications and every specialist in one plan.
Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.