Rare diseases · Sign or symptom
Intrauterine growth retardation
Prenatal growth deficiency
HP:0001511
What it means
An abnormal restriction of fetal growth with fetal weight below the tenth percentile for gestational age.
Intrauterine growth restriction is a newer term that is preferred over Intrauterine growth retardation. The causes of IUGR include maternal abnormalities (chronic hypertension, cyanotic heart disease, smoking, drug abuse), placental or umbilical cord abnormalities (including placenta previa and cord anomalies), maternal medicationas, and genetic disorders of the fetus.
Rare diseases that can present with this335
Very common80–99%
79- 12q14microdeletion syndrome
- 15q overgrowth syndrome
- 16p11.2p12.2microdeletion syndrome
- 19p13.3microduplication syndrome
- 19q13.11microdeletion syndrome
- 20q11.2microdeletion syndrome
- 3M syndrome
- 8p23.1microdeletion syndrome
- Antiphospholipid syndrome
- AREDYLD syndrome
- Atrioventricular defect-blepharophimosis-radial and anal defect syndrome
- Autosomal dominant spondylocostal dysostosis
- Autosomal recessive cutis laxa type 2, classic type
- Autosomal recessive spondylocostal dysostosis
- Bangstad syndrome
- Blepharophimosis-intellectual disability syndrome, Ohdo type
- Bloom syndrome
- Braddock syndrome
- Brain malformation-congenital heart disease-postaxial polydactyly syndrome
- Camptodactyly syndrome, Guadalajara type 2
- Cardiocranial syndrome, Pfeiffer type
- Chondrodysplasia-difference of sex development syndrome
- Cockayne syndrome type 2
- Congenital cataracts-facial dysmorphism-neuropathy syndrome
- Congenital osteogenesis imperfecta-microcephaly-cataracts syndrome
- Congenital rubella syndrome
- Congenital varicella syndrome
- Crane-Heise syndrome
- Craniosynostosis, Herrmann-Opitz type
- De Barsy syndrome
- Desmosterolosis
- Diastrophic dysplasia
- Distal deletion 15q syndrome
- Distal duplication 6p syndrome
- Dubowitz syndrome
- Ear-patella-short stature syndrome
- Eng-Strom syndrome
- Fetal akinesia deformation sequence
- Fetal alcohol syndrome
- Fetal trimethadione syndrome
- Genitopalatocardiac syndrome
- GRACILE syndrome
- Growth delay due to insulin-like growth factor I resistance
- Growth delay due to insulin-like growth factor type 1 deficiency
- Growth delay-hydrocephaly-lung hypoplasia syndrome
- Growth delay-intellectual disability-hepatopathy syndrome
- Harrod syndrome
- Hartsfield syndrome
- Holzgreve syndrome
- Hoyeraal-Hreidarsson syndrome
- Hydranencephaly
- Hyperinsulinism due to short chain 3-hydroxylacyl-CoA dehydrogenase deficiency
- IMAGe syndrome
- Intrauterine growth restriction-short stature-early adult-onset diabetes syndrome
- Isolated complex I deficiency
- Johanson-Blizzard syndrome
- Juberg-Hayward syndrome
- Lambert syndrome
- Lethal faciocardiomelic dysplasia
- Lipodystrophy-intellectual disability-deafness syndrome
- Maternal uniparental disomy of chromosome 2 syndrome
- Maternal uniparental disomy of chromosome 9 syndrome
- Methimazole embryofetopathy
- Microcephalic osteodysplastic primordial dwarfism type II
- Microcephalic osteodysplastic primordial dwarfism types I and III
- Microcephalic primordial dwarfism, Toriello type
- Microcephaly-cardiac defect-lung malsegmentation syndrome
- Monosomy 13q14 syndrome
- Monosomy X syndrome
- Mosaic monosomy X syndrome
- Mosaic trisomy 16 syndrome
- Mulibrey nanism
- Myhre syndrome
- Neu-Laxova syndrome
- Neurofaciodigitorenal syndrome
- Noonan syndrome with multiple lentigines
- Orofaciodigital syndrome type 4
- Osteogenesis imperfecta
- Paternal 20q13.2q13.3 microdeletion syndrome
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions, and Orphanet separately records 1 disease where this sign is specifically absent. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Fetal growth restriction · FGR · In utero growth retardation · Intrauterine growth failure · Intrauterine growth restriction · Intrauterine growth retardation, IUGR · Intrauterine retardation · IUGR
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.