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Start free with EleplanSheehan syndrome
ORPHA:91355Malformation syndrome
What it is
Sheehan syndrome is a rare, acquired, pituitary hormone deficiency disorder resulting from pituitary necrosis following peri- or postpartum hemorrhage characterized by various symptoms depending on resulting hormone decrease (e.g. failure or difficulty with lactation, oligo- or amenorrhea, hot flashes, decreased libido, weakness, fatigue, anorexia, nausea, vomiting, hypoglycemia, hyponatremia, dizziness, decreased muscle mass, adrenal crisis). Secondary hypothyroidism and secondary adrenal insufficiency may also be presenting signs.
Key facts
- Age of onset
- Adult
- Classified as
- Malformation syndrome
Signs and symptoms
Very common80–99%
7Common30–79%
23- Abnormal size of pituitary gland
- Amenorrhea
- Blurred vision
- Breast hypoplasia
- Central adrenal insufficiency
- Decreased female libido
- Decreased serum estradiol
- Dry skin
- Dyspareunia
- Gonadotropin deficiency
- Headache
- Hypoglycemia
- Hyposthenuria
- Impotence
- Nausea
- Normochromic anemia
- Orthostatic hypotension
- Pallor
- Pituitary hypothyroidism
- Progressive visual field defects
- Reduced circulating prolactin concentration
- Sparse axillary hair
- Sparse pubic hair
Sometimes5–29%
16- Antinuclear antibody positivity
- Arthralgia
- Bradycardia
- Chills
- Chronic lymphocytic meningitis
- Constipation
- Diplopia
- Hashimoto thyroiditis
and 8 more in this range
These ranges are how often a sign appears across everyone diagnosed, not a prediction for one person — most people have some of these and not others. Orphanet also records findings that are specifically absent in this disease; those are in the data but not listed here.
ICD-10 codes
ICD-10 has no distinct code for most rare diseases, so many are filed under the nearest available one. A shared code identifies the group, not this disease — the ORPHAcode above is what identifies it.
Related health topics
Reached through the ICD-10 categories this disease is filed under, so these describe the broader group rather than this disease specifically.
Benefit programs to look at
Programs whose eligibility touches the same ICD-10 categories. Eligibility is decided by the administering agency, never by this page.
Cross-references
Orphadata Science: Free access data from Orphanet. © INSERM 1999. Data version 2026-06-23. Available under CC BY 4.0. This is a reference, not medical advice.
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