Rare diseases · Sign or symptom
Oligomenorrhea
Light or infrequent menstrual periods
HP:0000876
What it means
Infrequent menses (less than 6 per year or more than 35 days between cycles).
Rare diseases that can present with this28
Very common80–99%
4Common30–79%
10- AKT2-related familial partial lipodystrophy
- Asherman syndrome
- Classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency
- Classic galactosemia
- Generalized glucocorticoid resistance syndrome
- Isolated follicle stimulating hormone deficiency
- Pituitary apoplexy
- Pituitary deficiency due to empty sella turcica syndrome
- Pituitary dermoid and epidermoid cysts
- PLIN1-related familial partial lipodystrophy
Sometimes5–29%
11- Acromegaly
- Blepharophimosis-ptosis-epicanthus inversus syndrome plus
- Cushing disease
- Cushing syndrome due to ectopic ACTH secretion
- Fowler urethral sphincter dysfunction syndrome
- Glycogen storage disease due to liver and muscle phosphorylase kinase deficiency
- Glycogen storage disease due to liver phosphorylase kinase deficiency
- Perrault syndrome
and 3 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.