Rare diseases · Sign or symptom
Central adrenal insufficiency
HP:0011734
What it means
A form of adrenal insufficiency related to a lack of ACTH, which leads to a decrease in the production of cortisol by the adrenal glands. Aldosterone production is not usually affected.
Rare diseases that can present with this14
Common30–79%
12- Craniopharyngioma
- Non-functioning pituitary adenoma
- Obesity due to prohormone convertase I deficiency
- Obesity due to pro-opiomelanocortin deficiency
- Pallister-Hall syndrome
- Prader-Willi syndrome due to maternal uniparental disomy of chromosome 15
- Prader-Willi syndrome due to paternal 15q11q13 deletion
- Prader-Willi syndrome due to paternal deletion of 15q11q13 type 1
- Prader-Willi syndrome due to paternal deletion of 15q11q13 type 2
- Prolactinoma
- Sheehan syndrome
- TSH-secreting pituitary adenoma
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Secondary adrenal insufficiency
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.