Rare diseases · Sign or symptom
Dry skin
HP:0000958
What it means
Skin characterized by the lack of natural or normal moisture.
Rare diseases that can present with this95
Very common80–99%
34- Acquired ichthyosis
- Acrodermatitis enteropathica
- Adult Refsum disease
- ADULT syndrome
- AGel amyloidosis
- Ataxia-photosensitivity-short stature syndrome
- Atopic keratoconjunctivitis
- Autosomal recessive hypohidrotic ectodermal dysplasia
- Cardiofaciocutaneous syndrome
- Classic mycosis fungoides
- Congenital ichthyosis-microcephalus-tetraplegia syndrome
- Congenital lethal erythroderma
- Distal duplication 6p syndrome
- Ectodermal dysplasia-intellectual disability-central nervous system malformation syndrome
- EEC syndrome
- Grubben-de Cock-Borghgraef syndrome
- Huriez syndrome
- Hypohidrotic ectodermal dysplasia
- Jung syndrome
- Juvenile dermatomyositis
- Lamellar ichthyosis
- Menkes disease
- Microcephalic primordial dwarfism, Montreal type
- Prolidase deficiency
- Recessive X-linked ichthyosis
- Rhizomelic chondrodysplasia punctata
- Sézary syndrome
- Sjögren-Larsson syndrome
- Spinocerebellar ataxia type 34
- Trichodysplasia-xeroderma syndrome
- Uremic pruritus
- Xeroderma pigmentosum
- Xeroderma pigmentosum-Cockayne syndrome complex
- X-linked intellectual disability, Nascimento type
Common30–79%
37- 19q13.11microdeletion syndrome
- Ablepharon macrostomia syndrome
- Aicardi-Goutières syndrome
- Amelo-onycho-hypohidrotic syndrome
- Autosomal dominant hypocalcemia
- Autosomal dominant palmoplantar keratoderma and congenital alopecia
- Beta-mercaptolactate cysteine disulfiduria
- Blau syndrome
- CHAND syndrome
- Complex regional pain syndrome
- Congenital hypothyroidism due to transplacental passage of TSH-binding inhibitory antibodies
- Congenital muscular dystrophy-respiratory failure-skin abnormalities-joint hyperlaxity syndrome
- Dermoodontodysplasia
- Erythrokeratodermia variabilis
- Familial melanoma
- Focal dermal hypoplasia
- Hereditary sensory and autonomic neuropathy type 4
- Hydroxykynureninuria
- Ichthyosis-alopecia-eclabion-ectropion-intellectual disability syndrome
- Isolated thyroid-stimulating hormone deficiency
- KRT1-related diffuse nonepidermolytic keratoderma
- Large/giant congenital melanocytic nevus
- Microcephalic osteodysplastic primordial dwarfism type II
- Naegeli-Franceschetti-Jadassohn syndrome
- Omenn syndrome
- Pellagra
- Pili torti-onychodysplasia syndrome
- Plague
- Rabson-Mendenhall syndrome
- Resistance to thyrotropin-releasing hormone syndrome
- Retinitis pigmentosa-intellectual disability-deafness-hypogonadism syndrome
- Sheehan syndrome
- Tangier disease
- Thyroid ectopia
- Ulerythema ophryogenesis
- Wolf-Hirschhorn syndrome
- Xeroderma pigmentosum variant
Sometimes5–29%
9- 21q22.11q22.12microdeletion syndrome
- 9p13microdeletion syndrome
- Acute adrenal insufficiency
- Addison disease
- Adiposis dolorosa
- ALG11-CDG
- Congenital hypothyroidism due to maternal intake of antithyroid drugs
- Congenital progressive bone marrow failure-B-cell immunodeficiency-skeletal dysplasia syndrome
and 1 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Xerosis
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.