Rare diseases · Sign or symptom
Decreased circulating cortisol level
Low blood cortisol level
HP:0008163
What it means
Abnormally reduced concentration of cortisol in the blood.
In everyday care
Most people with this sign do not have a rare disease — it appears in common conditions far more often. These general reference pages cover the same topic:
Rare diseases that can present with this21
Always100%
5Very common80–99%
8- 46,XY difference of sex development-adrenal insufficiency due to CYP11A1 deficiency
- Classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency
- Congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency
- Deficiency in anterior pituitary function-variable immunodeficiency syndrome
- Inherited isolated adrenal insufficiency due to partial CYP11A1 deficiency
- Sheehan syndrome
- X-linked adrenal hypoplasia congenita
- X-linked cerebral adrenoleukodystrophy
Common30–79%
8- Adenohypophysitis
- Congenital adrenal hyperplasia due to 17-alpha-hydroxylase deficiency
- Congenital adrenal hyperplasia due to 3-beta-hydroxysteroid dehydrogenase deficiency
- Congenital adrenal hyperplasia due to cytochrome P450 oxidoreductase deficiency
- Congenital lipoid adrenal hyperplasia due to STAR deficency
- Meningioma
- Panhypophysitis
- Triple A syndrome
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Decreased cortisol production · Glucocorticoid insufficiency · Hypocortisolemia · Hypocortisolism · Low to undetectable plasma cortisol · Plasma cortisol low
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.