Rare diseases · Sign or symptom
Psychosis
HP:0000709
What it means
A condition characterized by changes in personality and thought patterns, often accompanied by hallucinations and delusional beliefs, is known as psychosis.
Rare diseases that can present with this64
Common30–79%
11- Autoimmune limbic encephalitis
- Bilateral striopallidodentate calcinosis
- Cocaine intoxication
- Homocystinuria without methylmalonic aciduria
- MELAS
- Mixed connective tissue disease
- Norrie disease
- Prader-Willi syndrome due to maternal uniparental disomy of chromosome 15
- Prader-Willi syndrome due to paternal 15q11q13 deletion
- Prader-Willi syndrome due to paternal deletion of 15q11q13 type 1
- Prader-Willi syndrome due to paternal deletion of 15q11q13 type 2
Sometimes5–29%
40- 16p11.2p12.2microduplication syndrome
- 3q29microdeletion syndrome
- 48,XXYY syndrome
- Argininosuccinic aciduria
- Autosomal dominant spastic paraplegia type 9A
- Autosomal recessive spastic paraplegia type 11
- Autosomal recessive spastic paraplegia type 20
- Behavioral variant of frontotemporal dementia
and 32 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.