Rare diseases · Sign or symptom
Pallor
HP:0000980
What it means
Abnormally pale skin.
Rare diseases that can present with this75
Very common80–99%
20- Acute peripheral arterial occlusion
- Autoimmune hemolytic anemia, warm type
- Autosomal recessive malignant osteopetrosis
- Beta-thalassemia
- Beta-thalassemia major
- Cold agglutinin disease
- Congenital hyperinsulinism due to HNF4A deficiency
- Drug-induced autoimmune hemolytic anemia
- Hemoglobin Bart's fetalis syndrome
- Hereditary folate malabsorption
- Hereditary persistence of fetal hemoglobin-beta-thalassemia syndrome
- Infection-related hemolytic uremic syndrome
- Methylmalonic acidemia with homocystinuria, type cblD
- Mixed-type autoimmune hemolytic anemia
- Non-insulinoma pancreatogenous hypoglycemia syndrome
- Osteoporosis-oculocutaneous hypopigmentation syndrome
- Plummer-Vinson syndrome
- Spontaneous periodic hypothermia
- Thiamine-responsive megaloblastic anemia syndrome
- X-linked sideroblastic anemia
Common30–79%
36- Acquired idiopathic sideroblastic anemia
- Acute myelomonocytic leukemia
- Adenohypophysitis
- Alternating hemiplegia of childhood
- American trypanosomiasis
- Autosomal dominant hyperinsulinism due to Kir6.2 deficiency
- Autosomal dominant hyperinsulinism due to SUR1 deficiency
- Benign paroxysmal torticollis of infancy
- Beta-thalassemia intermedia
- Childhood absence epilepsy
- Diamond-Blackfan anemia
- Evans syndrome
- GATA2 deficiency spectrum
- Harlequin syndrome
- Hereditary spherocytosis
- Hyperinsulinism due to HNF1A deficiency
- Hyperinsulinism due to UCP2 deficiency
- Idiopathic hypereosinophilic syndrome
- Idiopathic pulmonary hemosiderosis
- Imerslund-Gräsbeck syndrome
- KCNQ2-related developmental and epileptic encephalopathy
- Leishmaniasis
- Multiple endocrine neoplasia type 2
- Multiple myeloma
- Non-functioning pituitary adenoma
- Panhypophysitis
- Primary myelofibrosis
- Prolactinoma
- Rheumatic fever
- Sepsis in premature infants
- Severe congenital hypochromic anemia with ringed sideroblasts
- Sheehan syndrome
- Systemic mastocytosis with associated hematologic neoplasm
- TSH-secreting pituitary adenoma
- Unstable beta globin chain variant disease
- Waldenström macroglobulinemia
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Paleness · Skin paleness
Pallor
Tracking symptoms like this for someone? Eleplan keeps symptoms, diagnoses, medications and every specialist in one plan.
Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.