Rare diseases · Sign or symptom
Diplopia
Double vision
HP:0000651
What it means
Diplopia is a condition in which a single object is perceived as two images, it is also known as double vision.
Rare diseases that can present with this85
Very common80–99%
12Common30–79%
22- Alexander disease
- Angiostrongyliasis
- Bickerstaff brainstem encephalitis
- Childhood-onset autosomal recessive slowly progressive spinocerebellar ataxia
- Encephalitis lethargica
- Episodic ataxia type 1
- Episodic ataxia type 4
- Familial or sporadic hemiplegic migraine
- Familial paroxysmal ataxia
- Hereditary late-onset Parkinson disease
- Juvenile nasopharyngeal angiofibroma
- Machado-Joseph disease type 1
- Machado-Joseph disease type 2
- Machado-Joseph disease type 3
- Miller Fisher syndrome
- Myasthenia gravis
- Paroxysmal dystonic choreathetosis with episodic ataxia and spasticity
- Pituitary apoplexy
- Pituitary dermoid and epidermoid cysts
- Spinocerebellar ataxia type 6
- Toxin-mediated infectious botulism
- Xeroderma pigmentosum-Cockayne syndrome complex
Sometimes5–29%
37- Adenohypophysitis
- Adult-onset autosomal recessive cerebellar ataxia
- African trypanosomiasis
- Amoebiasis due to free-living amoebae
- Arnold-Chiari malformation type I
- Charcot-Marie-Tooth disease type 4C
- Cysticercosis
- Deficiency in anterior pituitary function-variable immunodeficiency syndrome
and 29 more in this range
Rare1–4%
9- Congenital myasthenic syndrome
- Dural sinus malformation with arteriovenous shunt
- Leukoencephalopathy with brain stem and spinal cord involvement-high lactate syndrome
- Oguchi disease
- Pituitary deficiency due to empty sella turcica syndrome
- Pituitary deficiency due to Rathke cleft cysts
- Presynaptic congenital myasthenic syndrome
- Progressive multifocal leukoencephalopathy
and 1 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions, and Orphanet separately records 2 diseases where this sign is specifically absent. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.