Rare diseases · Sign or symptom
Hypoglycemia
Low blood sugar
HP:0001943
What it means
A decreased concentration of glucose in the blood.
In everyday care
Most people with this sign do not have a rare disease — it appears in common conditions far more often. These general reference pages cover the same topic:
Rare diseases that can present with this82
Very common80–99%
16- 3-hydroxy-3-methylglutaryl-CoA synthase deficiency
- 3-methylcrotonyl-CoA carboxylase deficiency
- Carnitine palmitoyl transferase 1A deficiency
- Endocardial fibroelastosis
- Fructose-1,6-bisphosphatase deficiency
- Glycogen storage disease due to glucose-6-phosphatase deficiency
- Glycogen storage disease due to glucose-6-phosphatase deficiency type Ib
- Glycogen storage disease due to glycogen debranching enzyme deficiency
- Histidinuria-renal tubular defect syndrome
- Hyperinsulinism due to INSR deficiency
- Isolated complex I deficiency
- Long chain 3-hydroxyacyl-CoA dehydrogenase deficiency
- Neonatal hemochromatosis
- Ornithine transcarbamylase deficiency
- Propionic acidemia
- Short stature due to GHSR deficiency
Common30–79%
23- Acute adrenal insufficiency
- Acute liver failure
- Beckwith-Wiedemann syndrome
- Combined pituitary hormone deficiencies, genetic forms
- Dopamine beta-hydroxylase deficiency
- Glycogen storage disease due to liver glycogen phosphorylase deficiency
- Glycogen storage disease due to liver phosphorylase kinase deficiency
- Holoprosencephaly
- HSD10 disease, infantile type
- Laron syndrome
- Malonic aciduria
- Multiple acyl-CoA dehydrogenase deficiency
- Non-acquired panhypopituitarism
- Pituitary apoplexy
- Pituitary stalk interruption syndrome
- Polyendocrine-polyneuropathy syndrome
- Primary microcephaly-mild intellectual disability-young-onset diabetes syndrome
- Pyridoxamine-5-phosphate deficiency-developmental and epileptic encephalopathy
- Pyruvate dehydrogenase E3 deficiency
- Recurrent metabolic encephalomyopathic crises-rhabdomyolysis-cardiac arrhythmia-intellectual disability syndrome
- Sheehan syndrome
- Simpson-Golabi-Behmel syndrome
- Triple A syndrome
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Hypoglycaemia
Tracking symptoms like this for someone? Eleplan keeps symptoms, diagnoses, medications and every specialist in one plan.
Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.