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ORPHA:2965Disease
Also called Lactotroph adenoma · PRL-secreting pituitary adenoma · PRLoma · Pituitary lactotrophic adenoma · Prolactin-secreting pituitary adenoma
What it is
A rare, usually benign, neoplasm of the anterior pituitary gland that results in hyperprolactinemia. The most common clinical manifestations are amenorrhea and infertility in women; and impotence, decreased libido and infertility in men.
Key facts
- Prevalence
- 1-5 / 10 000 (Europe)
- Age of onset
- Adolescent, Adult, Childhood, Elderly
- Inheritance
- Autosomal dominant
- Classified as
- Disease
Prevalence figures describe populations, not individuals, and are often estimates from a single study. Where the figure is an incidence or a birth prevalence, it says so.
Signs and symptoms
Very common80–99%
14Common30–79%
19- Abnormal hair quantity
- Adrenocorticotropic hormone deficiency
- Adrenocorticotropin deficient adrenal insufficiency
- Central adrenal insufficiency
- Decreased circulating ACTH level
- Dyspareunia
- Easy fatigability
- Fatigue
- Gynecomastia
- Headache
- Hypotension
- Nausea and vomiting
- Osteopenia
- Osteoporosis
- Pallor
- Pituitary hypothyroidism
- Progressive visual loss
- Secondary growth hormone deficiency
- Vomiting
These ranges are how often a sign appears across everyone diagnosed, not a prediction for one person — most people have some of these and not others. Orphanet also records findings that are specifically absent in this disease; those are in the data but not listed here.
Genes
ICD-10 codes
ICD-10 has no distinct code for most rare diseases, so many are filed under the nearest available one. A shared code identifies the group, not this disease — the ORPHAcode above is what identifies it.
Cross-references
Orphadata Science: Free access data from Orphanet. © INSERM 1999. Data version 2026-06-23. Available under CC BY 4.0. This is a reference, not medical advice.
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