Rare diseases · Sign or symptom
Male hypogonadism
Decreased function of male gonad
HP:0000026
What it means
Decreased functionality of the male gonad, i.e., of the testis, with reduced spermatogenesis or testosterone synthesis.
Rare diseases that can present with this23
Very common80–99%
11- 46,XX testicular difference of sex development
- 46,XY gonadal dysgenesis-motor and sensory neuropathy syndrome
- 48,XYYY syndrome
- 49,XXXYY syndrome
- 49,XYYYY syndrome
- Leydig cell hypoplasia
- Normosmic congenital hypogonadotropic hypogonadism
- Prolactinoma
- Ring chromosome Y syndrome
- X-linked intellectual disability, Cilliers type
- X-linked intellectual disability, Van Esch type
Common30–79%
4Sometimes5–29%
5The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.