Rare diseases · Sign or symptom
Irregular menstruation
Menstrual irregularity
HP:0000858
What it means
Abnormally high variation in the amount of time between periods.
Most women have between 11 and 13 menstrual periods each year. Bleeding usually lasts around 5 days (range: 2 to 7 days). When menstruation first starts, it can take up to 2 years to establish a regular cycle. After puberty, most women's menstruation is regular. The length of time between each period is similar. The normal menstrual cycle length is 28 (+/- 7) days days with the menstruation lasting between 2 and 7 days. It can take up to 2 years from menarche to develop a mature hypothalamic-pituitary-gonadal (HPG) axis. Within 1 year, 75 percent of girls have a cycle between 21 and 45 days. By the fifth gynecological year, 90 percent of girls will have regular cycles.
Rare diseases that can present with this17
Common30–79%
8- Congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency
- Congenital adrenal hyperplasia due to 17-alpha-hydroxylase deficiency
- Cushing syndrome due to bilateral macronodular adrenocortical disease
- Glycogen storage disease due to glucose-6-phosphatase deficiency type Ib
- Hidrotic ectodermal dysplasia, Halal type
- Hyperandrogenism due to cortisone reductase deficiency
- Non-functioning pituitary adenoma
- TSH-secreting pituitary adenoma
Sometimes5–29%
7The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Irregular menses · Irregular periods · Menstrual irregularities
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.