Rare diseases · Sign or symptom
Easy fatigability
HP:0003388
What it means
Increased susceptibility to fatigue.
Fatigue describes the inability to continue performing a task after multiple repetitions.
Rare diseases that can present with this31
Common30–79%
18- Central core disease
- Congenital fiber-type disproportion myopathy
- Congenital myasthenic syndrome
- Congenital myopathy with myasthenic-like onset
- Familial atrial myxoma
- Familial congenital mirror movements
- Glycogen storage disease due to lactate dehydrogenase M-subunit deficiency
- Isolated succinate-CoQ reductase deficiency
- Kyphoscoliotic Ehlers-Danlos syndrome due to FKBP22 deficiency
- Mitochondrial neurogastrointestinal encephalomyopathy
- Neutral lipid storage disease with myopathy
- Non-functioning pituitary adenoma
- Postsynaptic congenital myasthenic syndrome
- Presynaptic congenital myasthenic syndrome
- Progressive external ophthalmoplegia-myopathy-emaciation syndrome
- Progressive pseudorheumatoid dysplasia
- Prolactinoma
- TSH-secreting pituitary adenoma
Sometimes5–29%
12- Autosomal dominant progressive external ophthalmoplegia
- Bilateral striopallidodentate calcinosis
- Cap myopathy
- Combined oxidative phosphorylation defect type 23
- Congenitally corrected transposition of the great arteries
- Congenital myasthenic syndrome with glycosylation defect
- GMPPB-related limb-girdle muscular dystrophy R19
- Neurodevelopmental disorder-craniofacial dysmorphism-cardiac defect-skeletal anomalies syndrome due to 9q21.3 microdeletion
and 4 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Tired easily
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.