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Start free with EleplanAdenohypophysitis
ORPHA:95512Disease
Also called Anterior pituitary hypophysitis
What it is
A rare, acquired pituitary hormone deficiency, a type of primary hypophysitis characterized by an inflammation of anterior pituitary. Clinical presentation is variable and includes headaches, visual disturbances, symptoms of adrenal insufficiency, hyperprolactinemia, hypothyroidism and hypogonadism. It most commonly affects young women during pregnancy or postpartum period.
Key facts
- Age of onset
- Adolescent, Adult
- Classified as
- Disease
Recorded for the broader condition
- Inheritance
- Not applicablePrimary hypophysitis
Orphanet records these for the broader condition rather than for this specific form. They are a starting point, not a figure for this subtype — subtypes often differ, and some are defined by being rarer than the condition they sit under.
Signs and symptoms
Common30–79%
23- Abnormal size of pituitary gland
- Abnormal thalamic MRI signal intensity
- Adrenocorticotropic hormone deficiency
- Adrenocorticotropin deficient adrenal insufficiency
- Amenorrhea
- Blurred vision
- Decreased circulating cortisol level
- Decreased female libido
- Decreased male libido
- Decreased serum estradiol
- Decreased serum testosterone concentration
- Gonadotropin deficiency
- Headache
- Hyposthenuria
- Impotence
- Increased circulating prolactin concentration
- Nausea
- Normochromic anemia
- Orthostatic hypotension
- Pallor
- Pituitary hypothyroidism
- Progressive visual field defects
- Secondary growth hormone deficiency
These ranges are how often a sign appears across everyone diagnosed, not a prediction for one person — most people have some of these and not others. Orphanet also records findings that are specifically absent in this disease; those are in the data but not listed here.
ICD-10 codes
ICD-10 has no distinct code for most rare diseases, so many are filed under the nearest available one. A shared code identifies the group, not this disease — the ORPHAcode above is what identifies it.
Related health topics
Reached through the ICD-10 categories this disease is filed under, so these describe the broader group rather than this disease specifically.
Benefit programs to look at
Programs whose eligibility touches the same ICD-10 categories. Eligibility is decided by the administering agency, never by this page.
Cross-references
Orphadata Science: Free access data from Orphanet. © INSERM 1999. Data version 2026-06-23. Available under CC BY 4.0. This is a reference, not medical advice.
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