Rare diseases · Sign or symptom
Decreased serum testosterone concentration
Decreased serum testosterone level
HP:0040171
Rare diseases that can present with this33
Very common80–99%
17- 46,XY difference of sex development due to isolated 17,20-lyase deficiency
- 46,XY gonadal dysgenesis-motor and sensory neuropathy syndrome
- 46,XY partial gonadal dysgenesis
- 49,XXXYY syndrome
- 49,XYYYY syndrome
- Congenital adrenal hyperplasia due to 17-alpha-hydroxylase deficiency
- Intellectual disability-dysmorphism-hypogonadism-diabetes mellitus syndrome
- Isolated follicle stimulating hormone deficiency
- Leydig cell hypoplasia
- Normosmic congenital hypogonadotropic hypogonadism
- Obesity due to congenital leptin deficiency
- Obesity due to leptin receptor gene deficiency
- Primary hypergonadotropic hypogonadism-partial alopecia syndrome
- Progeria-short stature-pigmented nevi syndrome
- Testicular agenesis
- Woodhouse-Sakati syndrome
- X-linked intellectual disability, Cilliers type
Common30–79%
8Sometimes5–29%
6The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Decreased serum testosterone levels · Decreased testosterone · Low serum testosterone level · Low serum testosterone levels
Tracking symptoms like this for someone? Eleplan keeps symptoms, diagnoses, medications and every specialist in one plan.
Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.