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Start free with EleplanSystemic capillary leak syndrome
ORPHA:188Disease
Also called Capillary hyperpermeability syndrome · Capillary leak syndrome · Clarkson disease · Idiopathic capillary leak syndrome · SCLS
What it is
Systemic capillary leak syndrome (SCLS) is a severe systemic disease due to increased capillary permeability, characterized by episodes of hypotension, edema and hypovolemia.
Key facts
- Prevalence
- <1 / 1 000 000
- Age of onset
- Adult
- Inheritance
- Not applicable
- Classified as
- Disease
Prevalence figures describe populations, not individuals, and are often estimates from a single study. Where the figure is an incidence or a birth prevalence, it says so.
Signs and symptoms
Common30–79%
10Sometimes5–29%
11- Abnormal renal tubule morphology
- Arrhythmia
- Cardiorespiratory arrest
- Cough
- Multiple myeloma
- Myocarditis
- Oliguria
- Pericarditis
and 3 more in this range
These ranges are how often a sign appears across everyone diagnosed, not a prediction for one person — most people have some of these and not others. Orphanet also records findings that are specifically absent in this disease; those are in the data but not listed here.
ICD-10 codes
Related health topics
Reached through the ICD-10 categories this disease is filed under, so these describe the broader group rather than this disease specifically.
Cross-references
Orphadata Science: Free access data from Orphanet. © INSERM 1999. Data version 2026-06-23. Available under CC BY 4.0. This is a reference, not medical advice.
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