Rare diseases · Sign or symptom
Weight loss
HP:0001824
What it means
Reduction of total body weight.
Rare diseases that can present with this227
Very common80–99%
41- Acute adrenal insufficiency
- Addison disease
- Arginine vasopressin deficiency
- Autosomal dominant epidermolytic ichthyosis
- Benign recurrent intrahepatic cholestasis
- Bullous pemphigoid
- Congenital enterocyte heparan sulfate deficiency
- Drug reaction with eosinophilia and systemic symptoms
- Eosinophilic granulomatosis with polyangiitis
- Erdheim-Chester disease
- Erythrokeratodermia variabilis
- Familial colorectal cancer Type X
- Familial gestational hyperthyroidism
- Familial hyperthyroidism due to mutations in TSH receptor
- Familial pancreatic carcinoma
- Follicular lymphoma
- Galactose epimerase deficiency
- Giant cell arteritis
- Glucose-galactose malabsorption
- GM1 gangliosidosis
- Granulomatosis with polyangiitis
- Holocarboxylase synthetase deficiency
- Hutchinson-Gilford progeria syndrome
- Insulin-resistance syndrome type B
- Isolated permanent neonatal diabetes mellitus
- Late-onset isolated ACTH deficiency
- Lipodystrophy due to peptidic growth factors deficiency
- Lynch syndrome
- Majeed syndrome
- MALT lymphoma
- Nodular non-suppurative panniculitis
- Oculopharyngodistal myopathy
- Pemphigus vulgaris
- Perry syndrome
- PFAPA syndrome
- Polycythemia vera
- Stevens-Johnson syndrome
- Systemic lupus erythematosus
- Takayasu arteritis
- Toxic epidermal necrolysis
- Wilson disease
Common30–79%
39- 8p23.1microdeletion syndrome
- Acquired arginine vasopressin deficiency
- Acute myelomonocytic leukemia
- Acute promyelocytic leukemia
- Adrenocortical carcinoma
- Adult-onset Still disease
- African trypanosomiasis
- Aggressive systemic mastocytosis
- AIDS wasting syndrome
- AL amyloidosis
- Allergic bronchopulmonary aspergillosis
- Amyotrophic lateral sclerosis
- Aseptic abscess syndrome
- ATTRV30M amyloidosis
- Bronchial neuroendocrine tumor
- Brucellosis
- Cap polyposis
- Carney-Stratakis syndrome
- Castleman disease
- Chronic beryllium disease
- Chronic hiccup
- Chronic nonbacterial osteomyelitis/Chronic recurrent multifocal osteomyelitis
- Classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency
- Classic Hodgkin lymphoma
- Congenital fiber-type disproportion myopathy
- Congenital tufting enteropathy
- Cystic echinococcosis
- Dermatomyositis
- Desmoplastic small round cell tumor
- Diffuse alveolar hemorrhage
- Familial glucocorticoid deficiency
- Felty syndrome
- Gallbladder neuroendocrine tumor
- GATA2 deficiency spectrum
- Glucagonoma
- GRFoma
- Hereditary arginine vasopressin deficiency
- Hereditary pheochromocytoma-paraganglioma
- Hirschsprung disease
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Loss of weight
Weight loss
Tracking symptoms like this for someone? Eleplan keeps symptoms, diagnoses, medications and every specialist in one plan.
Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.