Rare diseases · Sign or symptom
Cough
Coughing
HP:0012735
What it means
A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation.
The European Respiratory Society Task Force recommended two possible definitions of cough: (1) A three-phase expulsive motor act characterized by an inspiratory effort (inspiratory phase) followed by a forced expiratory effort against a closed glottis (compressive phase) and then by opening of the glottis and rapid expiratory airflow (expulsive phase);and (2) A forced expiratory maneuver, usually against a closed glottis and associated with a characteristic sound. The term Cough or any of its more specific descendents can be modified by the terms Acute (HP:0011009), Subacute (HP:0011011), and Chronic (HP:0011010). In adults, an acute cough lasts less than 3 weeks, a subacute cough from 3 to 8 weeks, and a chronic cough longer than 8 weeks. In children aged less than 15 years a chronic cough is defined as a daily cough lasting for over 4 weeks.
In everyday care
Most people with this sign do not have a rare disease — it appears in common conditions far more often. These general reference pages cover the same topic:
Rare diseases that can present with this115
Very common80–99%
20- Allergic bronchopulmonary aspergillosis
- Anti-glomerular basement membrane disease
- Antisynthetase syndrome
- Aspergillosis
- Autosomal non-syndromic agammaglobulinemia
- Avian influenza
- Bronchiolitis obliterans
- Bronchopulmonary dysplasia
- Cryptogenic organizing pneumonia
- Hereditary motor and sensory neuropathy, Okinawa type
- Hughes-Stovin syndrome
- Legionnaires disease
- Lymphangioleiomyomatosis
- Lymphoid interstitial pneumonia
- Polymyositis
- Pulmonary blastoma
- Pulmonary non-tuberculous mycobacterial infection
- Scrub typhus
- Severe acute respiratory syndrome
- Staphylococcal necrotizing pneumonia
Common30–79%
46- Adenocarcinoma of the oesophagus and oesophagogastric junction
- Airway infantile hemangioma
- American trypanosomiasis
- Autosomal dominant hyper-IgE syndrome due to STAT3 deficiency
- Babesiosis
- Beta-ketothiolase deficiency
- Chronic beryllium disease
- Chronic pneumonitis of infancy
- Classic Hodgkin lymphoma
- Congenital pulmonary lymphangiectasia
- Congenital tracheomalacia
- Cryptococcosis
- Danon disease
- Diffuse alveolar hemorrhage
- Ebola hemorrhagic fever
- Febrile infection-related epilepsy syndrome
- Granulomatosis with polyangiitis
- Hepatic veno-occlusive disease-immunodeficiency syndrome
- High altitude pulmonary edema
- Hypocomplementemic urticarial vasculitis
- Idiopathic achalasia
- Idiopathic acute eosinophilic pneumonia
- Idiopathic pulmonary fibrosis
- Idiopathic pulmonary hemosiderosis
- Kaposiform lymphangiomatosis
- Langerhans cell histiocytosis
- Laryngotracheoesophageal cleft
- Lassa fever
- Lymphedema with yellow nails
- Mucopolysaccharidosis type 1
- Pleural mesothelioma
- Pontiac fever
- Pulmonary fibrosis-hepatic hyperplasia-bone marrow hypoplasia syndrome
- Pulmonary nodular lymphoid hyperplasia
- Relapsing polychondritis
- Sarcoidosis
- Squamous cell carcinoma of the esophagus
- Sternal cleft
- Stevens-Johnson syndrome/toxic epidermal necrolysis spectrum
- T-B+NK- severe combined immunodeficiency due to gamma chain deficiency
- Thymic carcinoma
- Thymic neuroendocrine tumor
- Thymoma-hypogammaglobulinemia syndrome
- Toxic epidermal necrolysis
- Triple A syndrome
- Zygomycosis
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.