Rare diseases · Sign or symptom
Pedal edema
Fluid accumulation in lower limbs
HP:0010741
What it means
An abnormal accumulation of excess fluid in the lower extremity resulting in swelling of the feet and extending upward to the lower leg.
Rare diseases that can present with this55
Very common80–99%
6Common30–79%
16- Alveolar echinococcosis
- Aortic arch interruption
- Chikungunya
- Complex regional pain syndrome
- Congenital analbuminemia
- GJC2-related late-onset primary lymphedema
- Idiopathic steroid-sensitive nephrotic syndrome with secondary steroid resistance
- Livedoid vasculopathy
- Meige disease
- Milroy disease
- Mueller-Weiss syndrome
- Osteochondrosis of the metatarsal bone
- Osteochondrosis of the tarsal bone
- PEHO syndrome
- Peripartum cardiomyopathy
- Pulmonary capillary hemangiomatosis
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Dependant edema · Dependant oedema · Edema of the lower limbs · Leg edema · Leg oedema · Lower leg swelling · Oedema of the lower limbs · Pedal oedema
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.