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Start free with EleplanLujo hemorrhagic fever
ORPHA:319213Disease
Also called Zambian hemorrhagic fever
What it is
Lujo hemorrhagic fever, caused by the Lujo virus (a newly discovered Old World arenavirus) is a zoonotic disease from Zambia, Africa, whose reservoir is unknown and is characterized by fever and hemorrhagic manifestations with an extremely high fatality rate of 80% (in the 5 reported cases to date) and a moderate to high level of nosocomial transmission.
Key facts
- Prevalence
- <1 / 1 000 000
- Age of onset
- All ages
- Classified as
- Disease
Prevalence figures describe populations, not individuals, and are often estimates from a single study. Where the figure is an incidence or a birth prevalence, it says so.
Signs and symptoms
Very common80–99%
10Common30–79%
22- Abnormality of the nervous system
- Chest pain
- Coma
- Confusion
- Ecchymosis
- Elevated circulating C-reactive protein concentration
- Generalized edema
- Increased circulating lactate dehydrogenase concentration
- Increased total leukocyte count
- Leukopenia
- Lymphopenia
- Maculopapular exanthema
- Metabolic acidosis
- Microscopic hematuria
- Nausea
- Oliguria
- Prolonged partial thromboplastin time
- Renal insufficiency
- Shock
- Skin rash
- Subconjunctival hemorrhage
- Vomiting
Sometimes5–29%
27- Abdominal cramps
- Anxiety
- Atelectasis
- Bilateral tonic-clonic seizure
- Bradycardia
- Cerebral edema
- Crackles
- Drowsiness
and 19 more in this range
These ranges are how often a sign appears across everyone diagnosed, not a prediction for one person — most people have some of these and not others. Orphanet also records findings that are specifically absent in this disease; those are in the data but not listed here.
ICD-10 codes
ICD-10 has no distinct code for most rare diseases, so many are filed under the nearest available one. A shared code identifies the group, not this disease — the ORPHAcode above is what identifies it.
Related health topics
Reached through the ICD-10 categories this disease is filed under, so these describe the broader group rather than this disease specifically.
Cross-references
Orphadata Science: Free access data from Orphanet. © INSERM 1999. Data version 2026-06-23. Available under CC BY 4.0. This is a reference, not medical advice.
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