Rare diseases · Sign or symptom
Crackles
HP:0030830
What it means
Crackles are discontinuous, explosive, and nonmusical adventitious lung sounds normally heard in inspiration and sometimes during expiration. Crackles are usually classified as fine and coarse crackles based on their duration, loudness, pitch, timing in the respiratory cycle, and relationship to coughing and changing body position.
Rales are fine, discontinuous crackles that can sound like cellophane being crumpled or velcro being pulled apart. They may be heard with a stethoscope when listening over lungs containing more than the normal amount of fluid secretiions.
Rare diseases that can present with this19
Common30–79%
10- Acute interstitial pneumonia
- Cardiogenic shock
- Congenital Gerbode defect
- Cryptogenic organizing pneumonia
- High altitude pulmonary edema
- Idiopathic bronchiectasis
- Idiopathic chronic eosinophilic pneumonia
- Idiopathic pulmonary fibrosis
- Lymphoid interstitial pneumonia
- Pulmonary fibrosis-hepatic hyperplasia-bone marrow hypoplasia syndrome
Sometimes5–29%
9- Autoimmune pulmonary alveolar proteinosis
- Complete atrioventricular septal defect
- Congenital heart block
- Exercise-induced malignant hyperthermia
- Hereditary pulmonary alveolar proteinosis
- Idiopathic pulmonary hemosiderosis
- Immunoglobulin A nephropathy
- Lujo hemorrhagic fever
and 1 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Crepitations · Rales
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.