Rare diseases · Sign or symptom
Elevated circulating C-reactive protein concentration
HP:0011227
What it means
The concentration of C-reactive protein in the blood circulation is above the upper limit of normal.
C-reactive protein (CRP) is produced by the liver, and increases in concentration in response to inflammation.
Rare diseases that can present with this62
Very common80–99%
14- Acquired hemophagocytic lymphohistiocytosis associated with malignant disease
- Adult-onset Still disease
- Aseptic abscess syndrome
- Autosomal dominant hereditary chronic pancreatitis
- CINCA syndrome
- Drug-induced lupus erythematosus
- Giant cell arteritis
- Interstitial granulomatous dermatitis with arthritis
- Juvenile dermatomyositis
- Malaria
- Relapsing fever
- Systemic-onset juvenile idiopathic arthritis
- TAFRO syndrome
- Tumor necrosis factor receptor 1 associated periodic syndrome
Common30–79%
30- Acquired purpura fulminans
- Acute lung injury
- Adiposis dolorosa
- Avian influenza
- Behçet disease
- Brucellosis
- Castleman disease
- Chronic nonbacterial osteomyelitis/Chronic recurrent multifocal osteomyelitis
- Classic Hodgkin lymphoma
- Eosinophilic gastroenteritis
- Generalized pustular psoriasis
- Granulomatosis with polyangiitis
- Heme oxygenase-1 deficiency
- Idiopathic chronic eosinophilic pneumonia
- IgG4-related aortitis
- IgG4-related ophthalmic disease
- IgG4-related pachymeningitis
- IgG4-related retroperitoneal fibrosis
- Interstitial cystitis
- Invasive meningococcal disease
- Kawasaki disease
- Lujo hemorrhagic fever
- Macrophage activation syndrome
- NAD(P)HX dehydratase deficiency
- Polyarteritis nodosa
- Postinfectious vasculitis
- Rheumatoid factor-positive polyarticular juvenile idiopathic arthritis
- Sepsis in premature infants
- Staphylococcal necrotizing pneumonia
- Sweet syndrome
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Elevated C-reactive protein concentration · Elevated C-reactive protein level · Elevated C-reactive protein level in blood · Elevated CRP · Increased C-reactive protein concentration · Increased C-reactive protein level · Increased C-reactive protein level in blood
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.