Rare diseases · Sign or symptom
Renal insufficiency
Renal failure
HP:0000083
What it means
A reduction in the level of performance of the kidneys in areas of function comprising the concentration of urine, removal of wastes, the maintenance of electrolyte balance, homeostasis of blood pressure, and calcium metabolism.
In everyday care
Most people with this sign do not have a rare disease — it appears in common conditions far more often. These general reference pages cover the same topic:
Rare diseases that can present with this180
Very common80–99%
18- Atresia of urethra
- Autosomal dominant polycystic kidney disease
- Autosomal recessive Alport syndrome
- Dent disease
- Fabry disease
- Fibronectin glomerulopathy
- HANAC syndrome
- Hepatic veno-occlusive disease
- HNF1B-related autosomal dominant tubulointerstitial kidney disease
- Indomethacin embryofetopathy
- Microscopic polyangiitis
- Multifocal infantile hemangioma with extracutenous involvement
- Nail-patella-like renal disease
- Oculocerebrorenal syndrome of Lowe
- Oligomeganephronia
- Pauci-immune glomerulonephritis
- Renal coloboma syndrome
- Severe oculo-renal-cerebellar syndrome
Common30–79%
57- Acrorenal syndrome
- Acute adrenal insufficiency
- Acute intermittent porphyria
- Adenine phosphoribosyltransferase deficiency
- ALECT2 amyloidosis
- Alport syndrome
- Alport syndrome-intellectual disability-midface hypoplasia-elliptocytosis syndrome
- Autosomal recessive polycystic kidney disease
- Boutonneuse fever
- CAMOS syndrome
- Carnitine palmitoyl transferase II deficiency, neonatal form
- Colchicine poisoning
- Congenital membranous nephropathy due to fetomaternal anti-neutral endopeptidase alloimmunization
- Cryoglobulinemic vasculitis
- Cystinosis
- Cystinuria
- Deafness-intellectual disability syndrome, Martin-Probst type
- Distal limb deficiencies-micrognathia syndrome
- Enamel-renal syndrome
- Frasier syndrome
- Genetic recurrent myoglobinuria
- Hereditary amyloidosis with primary renal involvement
- Hermansky-Pudlak syndrome
- Holoprosencephaly-caudal dysgenesis syndrome
- Hypocomplementemic urticarial vasculitis
- Hypoparathyroidism-sensorineural deafness-renal disease syndrome
- Idiopathic non-lupus full-house nephropathy
- IgG4-related kidney disease
- IgG4-related retroperitoneal fibrosis
- Isolated sedoheptulokinase deficiency
- Juvenile nephropathic cystinosis
- Laurence-Moon syndrome
- LCAT deficiency
- Lesch-Nyhan syndrome
- Lethal infantile mitochondrial myopathy
- Liddle syndrome
- Lujo hemorrhagic fever
- MYH9-related syndromic thrombocytopenia
- Nephronophthisis
- Nephropathy-deafness-hyperparathyroidism syndrome
- Pearson syndrome
- Pediatric systemic lupus erythematosus
- Phosphoribosylpyrophosphate synthetase superactivity
- Pierson syndrome
- Preeclampsia
- Primary membranoproliferative glomerulonephritis
- Prune belly syndrome
- Renal-hepatic-pancreatic dysplasia
- Renal hypoplasia
- Severe phosphoribosylpyrophosphate synthetase superactivity
- Syndactyly-telecanthus-anogenital and renal malformations syndrome
- TAFRO syndrome
- Thyrocerebrorenal syndrome
- Townes-Brocks syndrome
- Williams syndrome
- X-linked Alport syndrome
- Yellow fever
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Renal failure in adulthood
Tracking symptoms like this for someone? Eleplan keeps symptoms, diagnoses, medications and every specialist in one plan.
Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.