Rare diseases · Sign or symptom
Confusion
Disorientation
HP:0001289
What it means
Lack of clarity and coherence of thought, perception, understanding, or action.
Rare diseases that can present with this74
Very common80–99%
7Common30–79%
27- Acquired methemoglobinemia
- Acute liver failure
- Bacterial toxic-shock syndrome
- Behçet disease
- Citrullinemia type II
- Classic glucose transporter type 1 deficiency syndrome
- Ethylene glycol poisoning
- Familial or sporadic hemiplegic migraine
- Hyperornithinemia-hyperammonemia-homocitrullinuria syndrome
- Immune-mediated thrombotic thrombocytopenic purpura
- Infantile spasms-psychomotor retardation-progressive brain atrophy-basal ganglia disease syndrome
- Inhalational anthrax
- Inherited Creutzfeldt-Jakob disease
- Kufor-Rakeb syndrome
- Lafora disease
- Lujo hemorrhagic fever
- Manganese poisoning
- Mercury poisoning
- NAD(P)HX epimerase deficiency
- Serotonin syndrome
- Sporadic Creutzfeldt-Jakob disease
- Steroid-responsive encephalopathy associated with autoimmune thyroiditis
- Susac syndrome
- Thrombotic thrombocytopenic purpura
- Wiedemann-Rautenstrauch syndrome
- Xeroderma pigmentosum-Cockayne syndrome complex
- Xp21deletion syndrome
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Easily confused · Mental disorientation
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.