Rare diseases · Sign or symptom
Skin rash
HP:0000988
What it means
A red eruption of the skin.
In everyday care
Most people with this sign do not have a rare disease — it appears in common conditions far more often. These general reference pages cover the same topic:
Rare diseases that can present with this110
Very common80–99%
33- Adult-onset Still disease
- Autosomal dominant hyper-IgE syndrome due to STAT3 deficiency
- Autosomal non-syndromic agammaglobulinemia
- Benign cephalic histiocytosis
- Blau syndrome
- Blue rubber bleb nevus syndrome
- Boutonneuse fever
- Chronic mucocutaneous candidiasis
- Classic mycosis fungoides
- Congenital enterovirus infection
- Cutaneous collagenous vasculopathy
- Dracunculiasis
- Drug reaction with eosinophilia and systemic symptoms
- Erythema elevatum diutinum
- Erythrokeratodermia variabilis
- Hypocomplementemic urticarial vasculitis
- Immunoglobulin A vasculitis
- Juvenile dermatomyositis
- Kawasaki disease
- Malakoplakia
- Microscopic polyangiitis
- Mixed connective tissue disease
- Muckle-Wells syndrome
- Netherton syndrome
- Non-syndromic agammaglobulinemia
- Rothmund-Thomson syndrome
- Schnitzler syndrome
- Scrub typhus
- Systemic-onset juvenile idiopathic arthritis
- Tumor necrosis factor receptor 1 associated periodic syndrome
- Xeroderma pigmentosum-Cockayne syndrome complex
- X-linked agammaglobulinemia
- Zika virus disease
Common30–79%
34- Absence of fingerprints-congenital milia syndrome
- Acquired purpura fulminans
- American trypanosomiasis
- Biotinidase deficiency
- Bloom syndrome
- Chikungunya
- Chilblain lupus
- Congenital rubella syndrome
- Cutaneous small vessel vasculitis
- Dengue fever
- Dermatomyositis
- Eosinophilic granulomatosis with polyangiitis
- Familial hemophagocytic lymphohistiocytosis
- Familial tumoral calcinosis
- Gamma-heavy chain disease
- Glucagonoma
- Granulomatosis with polyangiitis
- Hartnup disease
- Hereditary angioedema with C1Inh deficiency
- Indolent systemic mastocytosis
- Invasive meningococcal disease
- Kikuchi-Fujimoto disease
- Langerhans cell histiocytosis
- Lujo hemorrhagic fever
- Mixed-type autoimmune hemolytic anemia
- Pediatric systemic lupus erythematosus
- Pellagra
- Q fever
- Rat-bite fever
- Reactive arthritis
- Reynolds syndrome
- Stevens-Johnson syndrome/toxic epidermal necrolysis spectrum
- T-B+NK- severe combined immunodeficiency due to gamma chain deficiency
- Typhoid
Sometimes5–29%
13- Acute liver failure
- Antisynthetase syndrome
- Bacterial toxic-shock syndrome
- Chédiak-Higashi syndrome
- Chronic nonbacterial osteomyelitis/Chronic recurrent multifocal osteomyelitis
- Classic Hodgkin lymphoma
- Coccidioidomycosis
- Combined immunodeficiency due to ZAP70 deficiency
and 5 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions, and Orphanet separately records 1 disease where this sign is specifically absent. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Rash
Tracking symptoms like this for someone? Eleplan keeps symptoms, diagnoses, medications and every specialist in one plan.
Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.