Rare diseases · Sign or symptom
Increased circulating lactate dehydrogenase concentration
HP:0025435
What it means
An elevated level of the enzyme lactate dehydrogenase in the blood circulation.
Lactate dehydrogenase catalyzes the interconversion of lactate and pyruvate.
Rare diseases that can present with this48
Very common80–99%
3Common30–79%
26- Acquired hemophagocytic lymphohistiocytosis associated with malignant disease
- Acyl-CoA dehydrogenase 9 deficiency
- Autoimmune hemolytic anemia, warm type
- Autoimmune pulmonary alveolar proteinosis
- Burkitt lymphoma
- Congenital bile acid synthesis defect type 2
- Crimean-Congo hemorrhagic fever
- Dehydrated hereditary stomatocytosis
- Dermatomyositis
- Genetic recurrent myoglobinuria
- Glycogen storage disease due to acid maltase deficiency
- Heme oxygenase-1 deficiency
- Hemolytic anemia due to glucophosphate isomerase deficiency
- Immune-mediated thrombotic thrombocytopenic purpura
- Kikuchi-Fujimoto disease
- Lujo hemorrhagic fever
- Lysinuric protein intolerance
- Myelodysplastic syndrome associated with isolated del(5q) chromosome abnormality
- Neutral lipid storage disease with myopathy
- Osteosarcoma
- Paroxysmal nocturnal hemoglobinuria
- Pediatric systemic lupus erythematosus
- PLA2G6-related neurodegeneration, infantile-onset
- Relapsing fever
- Rh deficiency syndrome
- Southeast Asian ovalocytosis
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Increased circulating LDH concentration · Increased lactate dehydrogenase level
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.