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Start free with EleplanSimple cryoglobulinemia
ORPHA:91139Disease
Also called Cryoglobulinemia type 1
What it is
Simple (monoclonal) cryoglobulinemia or type I cryoglobulinemia refers to the presence in the serum of one isotype or subclass of immunoglobulin (Ig) that precipitates reversibly below 37°C.
Key facts
- Age of onset
- Adult, Elderly
- Classified as
- Disease
Signs and symptoms
Common30–79%
12Sometimes5–29%
18- Abnormality of the kidney
- Arthralgia
- Arthritis
- B-cell lymphoma
- Hypertension
- Membranoproliferative glomerulonephritis
- Mesangial hypercellularity
- Microscopic hematuria
and 10 more in this range
These ranges are how often a sign appears across everyone diagnosed, not a prediction for one person — most people have some of these and not others. Orphanet also records findings that are specifically absent in this disease; those are in the data but not listed here.
ICD-10 codes
ICD-10 has no distinct code for most rare diseases, so many are filed under the nearest available one. A shared code identifies the group, not this disease — the ORPHAcode above is what identifies it.
Related health topics
Reached through the ICD-10 categories this disease is filed under, so these describe the broader group rather than this disease specifically.
Cross-references
Orphadata Science: Free access data from Orphanet. © INSERM 1999. Data version 2026-06-23. Available under CC BY 4.0. This is a reference, not medical advice.
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