Rare diseases · Sign or symptom
Increased circulating IgM concentration
HP:0003496
What it means
An abnormally increased level of immunoglobulin M in blood.
Rare diseases that can present with this20
Common30–79%
7Sometimes5–29%
9- Adult idiopathic neutropenia
- Angiostrongyliasis
- Brucellosis
- Hypohidrotic ectodermal dysplasia with immunodeficiency
- IgG4-related dacryoadenitis and sialadenitis
- Mucopolysaccharidosis-like syndrome with congenital heart defects and hematopoietic disorders
- Primary biliary cholangitis/primary sclerosing cholangitis and autoimmune hepatitis overlap syndrome
- Rift valley fever
and 1 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Increased IgM levels · Increased levels of IgM
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.