Rare diseases · Sign or symptom
Sensorimotor neuropathy
Nerve damage causing decreased feeling and movement
HP:0007141
Rare diseases that can present with this63
Very common80–99%
15- 46,XY gonadal dysgenesis-motor and sensory neuropathy syndrome
- Alacrimia-choreoathetosis-liver dysfunction syndrome
- Autosomal dominant Charcot-Marie-Tooth disease type 2E
- Autosomal recessive Charcot-Marie-Tooth disease with hoarseness
- Autosomal recessive spastic paraplegia type 11
- Autosomal recessive spastic paraplegia type 57
- Charcot-Marie-Tooth disease-deafness-intellectual disability syndrome
- Charcot-Marie-Tooth disease type 1F
- Charcot-Marie-Tooth disease type 4C
- Infantile Krabbe disease
- Mitochondrial neurogastrointestinal encephalomyopathy
- Sneddon syndrome
- Spinocerebellar ataxia with axonal neuropathy type 2
- X-linked Charcot-Marie-Tooth disease type 4
- X-linked Charcot-Marie-Tooth disease type 6
Common30–79%
32- AL amyloidosis
- Autosomal dominant Charcot-Marie-Tooth disease type 2Y
- Autosomal dominant optic atrophy, classic form
- Autosomal recessive cerebellar ataxia-movement disorder syndrome
- Autosomal recessive cerebellar ataxia with late-onset spasticity
- Autosomal recessive spastic ataxia of Charlevoix-Saguenay
- Autosomal recessive spastic paraplegia type 26
- Autosomal recessive spinocerebellar ataxia-blindness-deafness syndrome
- Autosomal spastic paraplegia type 30
- Cerebellar ataxia with neuropathy and bilateral vestibular areflexia syndrome
- Cockayne syndrome
- Congenital bile acid synthesis defect type 4
- Cryoglobulinemic vasculitis
- Early-onset spastic ataxia-myoclonic epilepsy-neuropathy syndrome
- Hereditary ATTR amyloidosis
- Hereditary neuropathy with liability to pressure palsies
- Juvenile-onset diabetes mellitus-central and peripheral neurodegeneration syndrome
- Late-infantile/juvenile Krabbe disease
- Mitochondrial DNA-associated Leigh syndrome
- Myoclonus-cerebellar ataxia-deafness syndrome
- PLA2G6-related neurodegeneration, infantile-onset
- Pontocerebellar hypoplasia type 10
- Roussy-Lévy syndrome
- Simple cryoglobulinemia
- Spastic paraplegia-neuropathy-poikiloderma syndrome
- Spinocerebellar ataxia type 18
- Spinocerebellar ataxia type 43
- Spinocerebellar ataxia with axonal neuropathy type 1
- Subacute inflammatory demyelinating polyneuropathy
- X-linked cerebral adrenoleukodystrophy
- X-linked Charcot-Marie-Tooth disease type 3
- X-linked progressive cerebellar ataxia
Sometimes5–29%
14- Adult Krabbe disease
- Adult-onset chronic progressive external ophthalmoplegia with mitochondrial myopathy
- Ataxia-oculomotor apraxia type 4
- Ataxia-telangiectasia-like disorder
- Autosomal dominant spastic paraplegia type 10
- Autosomal recessive spastic paraplegia type 25
- Gaucher disease
- Gaucher disease type 1
and 6 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Mixed polyneuropathy · Sensorimotor peripheral neuropathy
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.