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Start free with EleplanSystemic lupus erythematosus
ORPHA:536Disease
Also called Disseminated lupus erythematosus · SLE
What it is
Orphanet has not published a description for this disease yet. The identifiers, classification and cross-references below are still current.
Key facts
- Prevalence
- 1-5 / 10 000
- Age of onset
- Adolescent, Adult, Childhood, Infancy
- Inheritance
- Not applicable
- Classified as
- Disease
Prevalence figures describe populations, not individuals, and are often estimates from a single study. Where the figure is an incidence or a birth prevalence, it says so.
Signs and symptoms
Common30–79%
16- Alopecia
- Anti-complement component C1q antibody positivity
- Antineutrophil antibody positivity
- Anti-ribosome Po antibody positivity
- Anti-titin antibody positivity
- Arthritis
- Decreased circulating complement C3 concentration
- Decreased circulating complement C4 concentration
- Hematuria
- Hypertension
- Leukopenia
- Lupus nephritis
- Malar rash
- Polyarticular arthritis
- Pyuria
- Raynaud phenomenon
Sometimes5–29%
19- Abnormality of salivation
- Abnormal pigmentation of the oral mucosa
- Anti-dsDNA antibody positivity
- Anti-La/SS-B antibody positivity
- Anti-nucleoporin 62 antibody positivity
- Anti-phosphatidic acid antibody positivity
- Anti-Ro52/TRIM21 antibody positivity
- Anti-Sm antibody positivity
and 11 more in this range
These ranges are how often a sign appears across everyone diagnosed, not a prediction for one person — most people have some of these and not others. Orphanet also records findings that are specifically absent in this disease; those are in the data but not listed here.
Genes
1 modifying gene — variants that can change how the disease behaves, not cause it
ICD-10 codes
ICD-10 has no distinct code for most rare diseases, so many are filed under the nearest available one. A shared code identifies the group, not this disease — the ORPHAcode above is what identifies it.
Related health topics
Reached through the ICD-10 categories this disease is filed under, so these describe the broader group rather than this disease specifically.
Cross-references
Orphadata Science: Free access data from Orphanet. © INSERM 1999. Data version 2026-06-23. Available under CC BY 4.0. This is a reference, not medical advice.
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