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Start free with EleplanEssential thrombocythemia
ORPHA:3318Disease
Also called ET · Essential thrombocytosis
What it is
Essential thrombocythemia (ET) is a myeloproliferative neoplasm (MPN) characterized by a sustained elevation of platelet number (> 450 x 109/L) with a tendency for thrombosis and hemorrhage.
Key facts
- Prevalence
- 1-5 / 10 000 (United States)
- Age of onset
- All ages
- Inheritance
- Multigenic/multifactorial, Not applicable
- Classified as
- Disease
Prevalence figures describe populations, not individuals, and are often estimates from a single study. Where the figure is an incidence or a birth prevalence, it says so.
Signs and symptoms
Very common80–99%
15- Abnormality of bone marrow cell morphology
- Abnormality of the cerebral vasculature
- Abnormality of thrombocytes
- Abnormal platelet morphology
- Amaurosis fugax
- Arterial thrombosis
- Chest pain
- Fatigue
- Increased megakaryocyte count
- Megakaryocyte nucleus hyperlobulation
- Myocardial infarction
- Paresthesia
- Prolonged bleeding time
- Thrombocytosis
- Venous thrombosis
These ranges are how often a sign appears across everyone diagnosed, not a prediction for one person — most people have some of these and not others. Orphanet also records findings that are specifically absent in this disease; those are in the data but not listed here.
Genes
ICD-10 codes
Related health topics
Reached through the ICD-10 categories this disease is filed under, so these describe the broader group rather than this disease specifically.
Cross-references
Orphadata Science: Free access data from Orphanet. © INSERM 1999. Data version 2026-06-23. Available under CC BY 4.0. This is a reference, not medical advice.
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