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Start free with EleplanOverlap myositis
ORPHA:206572Disease
Also called Adult-onset overlap myositis · Non-specific myositis
What it is
A rare idiopathic inflammatory myopathy (IIM) with a heterogeneous phenotype characterized by myositis with at least one clinical and/or autoantibody overlap feature. Possible clinical overlap features include polyarthritis, Raynaud's phenomenon, sclerodactyly, scleroderma (proximal to metacarpophalangeal joints), lung interstitial pneumonia, and/or clinical signs of systemic lupus erythematosus (SLE).
Key facts
- Age of onset
- Adult
- Inheritance
- Not applicable
- Classified as
- Disease
Signs and symptoms
Common30–79%
21- Abnormal circulating lipid concentration
- Anti-Ku antibody positivity
- Antinuclear antibody positivity
- Anti-PM-Scl antibody positivity
- Anti-Ro52/TRIM21 antibody positivity
- Anti-Ro/SS-A antibody positivity
- Anti-Sm antibody positivity
- Anti-topoisomerase I antibody positivity
- Arthritis
- Autoimmunity
- Constitutional symptom
- Dysphagia
- Elevated circulating creatine kinase concentration
- Finger swelling
- Hypertension
- Perifascicular muscle fiber atrophy
- Proximal muscle weakness
- Proximal muscle weakness in upper limbs
- Raynaud phenomenon
- Sclerodactyly
- Severe infection
These ranges are how often a sign appears across everyone diagnosed, not a prediction for one person — most people have some of these and not others. Orphanet also records findings that are specifically absent in this disease; those are in the data but not listed here.
ICD-10 codes
ICD-10 has no distinct code for most rare diseases, so many are filed under the nearest available one. A shared code identifies the group, not this disease — the ORPHAcode above is what identifies it.
Related health topics
Reached through the ICD-10 categories this disease is filed under, so these describe the broader group rather than this disease specifically.
Cross-references
Orphadata Science: Free access data from Orphanet. © INSERM 1999. Data version 2026-06-23. Available under CC BY 4.0. This is a reference, not medical advice.
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