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Start free with EleplanFamilial calcium pyrophosphate deposition
ORPHA:1416Disease
Also called Calcium pyrophosphate dihydrate crystal deposition disease · Familial CC · Familial CPPD · Familial articular chondrocalcinosis · Hereditary CC · Hereditary articular chondrocalcinosis · Hereditary calcium pyrophosphate deposition
What it is
A rare inherited rheumatologic disease which causes calcification of articular fibrocartilage or hyaline cartilage, a process termed chondrocalcinosis (CC). It often associates with acute synovitis and osteoarthritis (OA).
Key facts
- Age of onset
- Adult
- Inheritance
- Autosomal dominant, Not applicable
- Classified as
- Disease
Signs and symptoms
Very common80–99%
5Sometimes5–29%
10- Ankylosis
- Chondrocalcinosis
- Decreased body mass index
- Fever
- Increased inflammatory response
- Joint dislocation
- Joint stiffness
- Limitation of joint mobility
and 2 more in this range
These ranges are how often a sign appears across everyone diagnosed, not a prediction for one person — most people have some of these and not others. Orphanet also records findings that are specifically absent in this disease; those are in the data but not listed here.
Genes
ICD-10 codes
Related health topics
Reached through the ICD-10 categories this disease is filed under, so these describe the broader group rather than this disease specifically.
Cross-references
Orphadata Science: Free access data from Orphanet. © INSERM 1999. Data version 2026-06-23. Available under CC BY 4.0. This is a reference, not medical advice.
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