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Start free with EleplanOsteochondrosis of the metatarsal bone
ORPHA:564003Disease
Also called Avascular necrosis of the metatarsal bone · Freiberg disease · Freiberg infraction
What it is
A rare bone disease characterized by avascular necrosis of a metatarsal head, most commonly involving the second, but also the third or fourth, metatarsal. Patients may present with pain on weight-bearing, swelling, and tenderness. Radiological features include widening of the metatarsophalangeal joint space and flattening of the affected metatarsal head, at later stages metatarsal head sclerosis, cortical thickening, and intra-articular loose bodies. The condition can be bilateral in some cases and shows a significant predilection for females in the second or third decade of life.
Key facts
- Age of onset
- Adolescent, Adult
- Inheritance
- Not applicable
- Classified as
- Disease
Signs and symptoms
Common30–79%
15These ranges are how often a sign appears across everyone diagnosed, not a prediction for one person — most people have some of these and not others. Orphanet also records findings that are specifically absent in this disease; those are in the data but not listed here.
ICD-10 codes
Cross-references
Orphadata Science: Free access data from Orphanet. © INSERM 1999. Data version 2026-06-23. Available under CC BY 4.0. This is a reference, not medical advice.
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