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Start free with EleplanExercise-induced malignant hyperthermia
ORPHA:466650Disease
Also called Exertional heat stroke
What it is
A rare disease with malignant hyperthermia characterized by exercise-induced life-threatening hyperthermia with a body temperature over 40°C and signs of encephalopathy ranging from confusion to convulsions or coma. Incidence increases with rising ambient temperature and relative humidity. Manifestations may include rhabdomyolysis (presenting with myalgia, muscle weakness, and myoglobinuria), tachycardia, and in severe cases multiorgan failure.
Key facts
- Age of onset
- All ages
- Inheritance
- Multigenic/multifactorial
- Classified as
- Disease
Signs and symptoms
Sometimes5–29%
24- Abnormal bleeding
- Abnormality of the coagulation cascade
- Abnormal T-wave
- Ataxia
- Confusion
- Crackles
- Decreased liver function
- Delirium
and 16 more in this range
These ranges are how often a sign appears across everyone diagnosed, not a prediction for one person — most people have some of these and not others. Orphanet also records findings that are specifically absent in this disease; those are in the data but not listed here.
Gene
ICD-10 codes
ICD-10 has no distinct code for most rare diseases, so many are filed under the nearest available one. A shared code identifies the group, not this disease — the ORPHAcode above is what identifies it.
Related health topics
Reached through the ICD-10 categories this disease is filed under, so these describe the broader group rather than this disease specifically.
Cross-references
Orphadata Science: Free access data from Orphanet. © INSERM 1999. Data version 2026-06-23. Available under CC BY 4.0. This is a reference, not medical advice.
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