Rare diseases · Sign or symptom
Hepatic failure
Liver failure
HP:0001399
Rare diseases that can present with this63
Very common80–99%
10- Carnitine palmitoyl transferase 1A deficiency
- Chronic neurovisceral acid sphingomyelinase deficiency
- Lysosomal acid lipase deficiency
- Maternal uniparental disomy of chromosome X syndrome
- Müllerian derivatives-lymphangiectasia-polydactyly syndrome
- Odontomatosis-aortae esophagus stenosis syndrome
- Ornithine transcarbamylase deficiency
- Steroid dehydrogenase deficiency-dental anomalies syndrome
- Wolman disease
- Zellweger syndrome
Common30–79%
12- Carnitine palmitoyl transferase II deficiency, neonatal form
- Cholesteryl ester storage disease
- Citrullinemia type I
- Classic galactosemia
- Congenital bile acid synthesis defect type 2
- Congenital bile acid synthesis defect type 3
- Hepatoencephalopathy due to combined oxidative phosphorylation defect type 1
- Lathosterolosis
- Lysinuric protein intolerance
- MEGDEL syndrome
- Parenteral nutrition-associated cholestasis
- Primary biliary cholangitis
Sometimes5–29%
24- Acquired hemophagocytic lymphohistiocytosis associated with malignant disease
- Acquired purpura fulminans
- Alström syndrome
- Argininosuccinic aciduria
- Babesiosis
- Carnitine-acylcarnitine translocase deficiency
- Carnitine palmitoyl transferase II deficiency, severe infantile form
- Caroli syndrome
and 16 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Hepatic insufficiency
Tracking symptoms like this for someone? Eleplan keeps symptoms, diagnoses, medications and every specialist in one plan.
Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.