Rare diseases · Sign or symptom
Decreased liver function
Liver dysfunction
HP:0001410
What it means
Reduced ability of the liver to perform its functions.
Rare diseases that can present with this31
Very common80–99%
3Common30–79%
14- ALG3-CDG
- Alveolar echinococcosis
- Chédiak-Higashi syndrome
- Chronic visceral acid sphingomyelinase deficiency
- COG2-CDG
- Congenital lactic acidosis, Saguenay-Lac-Saint-Jean type
- Familial hemophagocytic lymphohistiocytosis
- Hyperornithinemia-hyperammonemia-homocitrullinuria syndrome
- Isolated biliary atresia
- Medium chain acyl-CoA dehydrogenase deficiency
- Methotrexate toxicity
- MPI-CDG
- Non-progressive predominantly posterior cavitating leukoencephalopathy with peripheral neuropathy
- Sarcoidosis
Sometimes5–29%
13- 3-methylglutaconic aciduria type 4
- Aggressive systemic mastocytosis
- ALG1-CDG
- Autosomal erythropoietic protoporphyria
- Beta-thalassemia intermedia
- Congenital cerebellar ataxia due to RNU12 mutation
- Exercise-induced malignant hyperthermia
- Galactose mutarotase deficiency
and 5 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Hepatopathy · Liver dysfunction, mild
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.