Rare diseases · Sign or symptom
Rhabdomyolysis
Breakdown of skeletal muscle
HP:0003201
What it means
Breakdown of muscle fibers that leads to the release of muscle fiber contents (myoglobin) into the bloodstream.
Rare diseases that can present with this26
Very common80–99%
2Common30–79%
3Sometimes5–29%
8- Carnitine palmitoyltransferase II deficiency
- Carnitine palmitoyl transferase II deficiency, myopathic form
- Carnitine palmitoyl transferase II deficiency, severe infantile form
- Congenital bile acid synthesis defect type 4
- Fatal infantile lactic acidosis with methylmalonic aciduria
- Glycogen storage disease due to lactate dehydrogenase deficiency
- Neuroleptic malignant syndrome
- Snakebite envenomation
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions, and Orphanet separately records 1 disease where this sign is specifically absent. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.