Rare diseases · Sign or symptom
Venous thrombosis
Blood clot in vein
HP:0004936
What it means
Formation of a blood clot (thrombus) inside a vein, causing the obstruction of blood flow.
Rare diseases that can present with this45
Very common80–99%
5Common30–79%
14- AA amyloidosis
- Antiphospholipid syndrome
- Behçet disease
- Capillary-lymphatic-venous malformation with segmental distribution
- Catastrophic antiphospholipid syndrome
- Classic heparin-induced thrombocytopenia
- Eosinophilic granulomatosis with polyangiitis
- Familial dysfibrinogenemia
- Homocystinuria due to cystathionine beta-synthase deficiency
- Microscopic polyangiitis
- Paroxysmal nocturnal hemoglobinuria
- Segmental venous malformation
- Severe hereditary thrombophilia due to congenital protein C deficiency
- TEMPI syndrome
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions, and Orphanet separately records 1 disease where this sign is specifically absent. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.