Classic mycosis fungoides

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Classic mycosis fungoides

ORPHA:2584Disease

Also called Mycosis fungoides, Alibert-Bazin type

What it is

A form of cutaneous T-cell lymphoma characterized by slow progression from patches to more infiltrated plaques and eventually to tumors. In classic mycosis fungoides (MF), extracutaneous involvement may occur.

Key facts

Prevalence
1-9 / 1 000 000 (annual incidence, Europe)
Age of onset
Adult
Inheritance
Multigenic/multifactorial, Not applicable
Classified as
Disease

Prevalence figures describe populations, not individuals, and are often estimates from a single study. Where the figure is an incidence or a birth prevalence, it says so.

Signs and symptoms

These ranges are how often a sign appears across everyone diagnosed, not a prediction for one person — most people have some of these and not others. Orphanet also records findings that are specifically absent in this disease; those are in the data but not listed here.

Genes

TNFRSF1BDisease-causing somatic mutation(s)
CD28Part of a fusion gene
CTLA4Part of a fusion gene

ICD-10 codes

C84.0filed under a broader ICD-10 category — shared with 4 other rare diseases

ICD-10 has no distinct code for most rare diseases, so many are filed under the nearest available one. A shared code identifies the group, not this disease — the ORPHAcode above is what identifies it.

Related health topics

Reached through the ICD-10 categories this disease is filed under, so these describe the broader group rather than this disease specifically.

Cross-references

GARD 3863MONDO 0009691OMIM 254400UMLS C4707404

Orphadata Science: Free access data from Orphanet. © INSERM 1999. Data version 2026-06-23. Available under CC BY 4.0. This is a reference, not medical advice.

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