Rare diseases · Sign or symptom
Lymphadenopathy
Swollen lymph nodes
HP:0002716
What it means
Enlargement (swelling) of a lymph node.
Rare diseases that can present with this125
Very common80–99%
23- Adenocarcinoma of the anal canal
- Autoimmune hemolytic anemia-autoimmune thrombocytopenia-primary immunodeficiency syndrome due to TPP2 deficiency
- Autoimmune lymphoproliferative syndrome
- Autosomal recessive malignant osteopetrosis
- Castleman disease
- Cat-scratch disease
- Classic Hodgkin lymphoma
- Desmoplastic small round cell tumor
- Drug reaction with eosinophilia and systemic symptoms
- Follicular lymphoma
- Hyperimmunoglobulinemia D with periodic fever
- Leishmaniasis
- Lymphatic filariasis
- Mantle cell lymphoma
- Mendelian susceptibility to mycobacterial diseases due to partial IRF8 deficiency
- Nodular lymphocyte predominant Hodgkin lymphoma
- Omenn syndrome
- PFAPA syndrome
- Pulmonary capillary hemangiomatosis
- Rosaï-Dorfman disease
- Sézary syndrome
- Squamous cell carcinoma of the anal canal
- TAFRO syndrome
Common30–79%
46- Activated PI3K-delta syndrome
- Activated PI3K-delta syndrome 1
- Activated PI3K-delta syndrome 2
- Adult-onset Still disease
- African trypanosomiasis
- Aggressive systemic mastocytosis
- American trypanosomiasis
- Anaplastic thyroid carcinoma
- Autoimmune lymphoproliferative syndrome due to CTLA4 haploinsuffiency
- Boutonneuse fever
- CINCA syndrome
- Classic mycosis fungoides
- Combined immunodeficiency due to CRAC channel dysfunction
- Cyclic neutropenia
- Familial hemophagocytic lymphohistiocytosis
- Familial pancreatic carcinoma
- Felty syndrome
- Gamma-heavy chain disease
- Griscelli syndrome
- Griscelli syndrome type 2
- Hennekam syndrome
- H syndrome
- IgG4-related ophthalmic disease
- IgG4-related submandibular gland disease
- Ileal neuroendocrine tumor
- Kerion celsi
- Kikuchi-Fujimoto disease
- Kimura disease
- Langerhans cell histiocytosis
- Lymphangioleiomyomatosis
- Macrophage activation syndrome
- Mast cell sarcoma
- Medullary thyroid carcinoma
- Mu-heavy chain disease
- Neuroblastoma
- PAPA syndrome
- Pediatric systemic lupus erythematosus
- Perihilar cholangiocarcinoma
- POEMS syndrome
- Post-transplant lymphoproliferative disease
- Rhabdoid tumor
- Roifman syndrome
- Scrub typhus
- Systemic-onset juvenile idiopathic arthritis
- Thyroid lymphoma
- Tumor necrosis factor receptor 1 associated periodic syndrome
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions, and Orphanet separately records 3 diseases where this sign is specifically absent. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Lymph node hyperplasia
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.