Rare diseases · Sign or symptom
Eczematoid dermatitis
Eczema
HP:0000964
What it means
Eczema is a form of dermatitis that is characterized by scaly, pruritic, erythematous lesions located on flexural surfaces.
The term eczema is broadly applied to a range of persistent skin conditions and can be related to a number of underlying conditions. Manifestations of eczema can include dryness and recurring skin rashes with redness, skin edema, itching and dryness, crusting, flaking, blistering, cracking, oozing, or bleeding. Eczema has several forms including atopic dermatitis, contact dermatitis, dyshidrotic eczema, nummular eczema, seborrheic dermatitis, and stasis dermatitis.
In everyday care
Most people with this sign do not have a rare disease — it appears in common conditions far more often. These general reference pages cover the same topic:
Rare diseases that can present with this63
Very common80–99%
11- Autosomal dominant hyper-IgE syndrome due to STAT3 deficiency
- Bullous pemphigoid
- Chronic actinic dermatitis
- Classic mycosis fungoides
- Craniosynostosis-anal anomalies-porokeratosis syndrome
- Grubben-de Cock-Borghgraef syndrome
- Hereditary acrokeratotic poikiloderma
- Intellectual disability-seizures-macrocephaly-obesity syndrome
- Netherton syndrome
- PGM3-CDG
- Xq12-q13.3 duplication syndrome
Common30–79%
18- 2q37microdeletion syndrome
- Acral peeling skin syndrome
- Dermatitis herpetiformis
- Dubowitz syndrome
- Hypohidrotic ectodermal dysplasia
- Ichthyosis follicularis-alopecia-photophobia syndrome
- Immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome
- Langerhans cell histiocytosis
- Laron syndrome with immunodeficiency
- Loeys-Dietz syndrome
- Lymphoid interstitial pneumonia
- Maternal uniparental disomy of chromosome 6 syndrome
- Nicolaides-Baraitser syndrome
- Phenylketonuria
- Pili torti-onychodysplasia syndrome
- Roifman syndrome
- Short stature-brachydactyly-obesity-global developmental delay syndrome
- STAT1-related autoimmune enteropathy and endocrinopathy-susceptibility to chronic infections syndrome
Sometimes5–29%
29- 8q21.11microdeletion syndrome
- Agammaglobulinemia-microcephaly-craniosynostosis-severe dermatitis syndrome
- Argininosuccinic aciduria
- Autism spectrum disorder due to AUTS2 deficiency
- Autoimmune lymphoproliferative syndrome due to CTLA4 haploinsuffiency
- Autosomal dominant hypocalcemia
- Autosomal dominant hypohidrotic ectodermal dysplasia
- Autosomal erythropoietic protoporphyria
and 21 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Dermatitis
Tracking symptoms like this for someone? Eleplan keeps symptoms, diagnoses, medications and every specialist in one plan.
Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.