Rare diseases · Sign or symptom
Alopecia
Hair loss
HP:0001596
What it means
A noncongenital process of hair loss, which may progress to partial or complete baldness.
In everyday care
Most people with this sign do not have a rare disease — it appears in common conditions far more often. These general reference pages cover the same topic:
Rare diseases that can present with this138
Very common80–99%
35- Acrodermatitis enteropathica
- Alopecia-contractures-dwarfism-intellectual disability syndrome
- Alopecia-intellectual disability syndrome
- Atypical Werner syndrome
- Björnstad syndrome
- BRESEK syndrome
- Cronkhite-Canada syndrome
- Distal deletion 19p syndrome
- Encephalocraniocutaneous lipomatosis
- Epidermolysis bullosa simplex with muscular dystrophy
- Frontonasal dysplasia-alopecia-genital anomalies syndrome
- GAPO syndrome
- Graham Little-Piccardi-Lassueur syndrome
- Hallermann-Streiff syndrome
- Hereditary mucoepithelial dysplasia
- Hypohidrotic ectodermal dysplasia-hypothyroidism-ciliary dyskinesia syndrome
- Hypotrichosis-lymphedema-telangiectasia-renal defect syndrome
- Hypotrichosis simplex
- Ichthyosis follicularis-alopecia-photophobia syndrome
- Johanson-Blizzard syndrome
- Johnson neuroectodermal syndrome
- Lichen planopilaris
- Linear nevus sebaceus syndrome
- Mandibuloacral dysplasia with type A lipodystrophy
- Marie Unna hereditary hypotrichosis
- Microcephalic osteodysplastic primordial dwarfism types I and III
- Nicolaides-Baraitser syndrome
- Odonto-onycho dysplasia-alopecia syndrome
- Omenn syndrome
- Primary hypergonadotropic hypogonadism-partial alopecia syndrome
- Progeria-short stature-pigmented nevi syndrome
- Pseudopelade of Brocq
- Pseudoprogeria syndrome
- Thumb deformity-alopecia-pigmentation anomaly syndrome
- Woodhouse-Sakati syndrome
Common30–79%
42- ADULT syndrome
- ANE syndrome
- Autoimmune polyendocrinopathy type 2
- Autosomal dominant generalized epidermolysis bullosa simplex, severe form
- Autosomal dominant hypocalcemia
- Autosomal recessive hypohidrotic ectodermal dysplasia
- Brain malformation-congenital heart disease-postaxial polydactyly syndrome
- Chronic graft versus host disease
- Classic mycosis fungoides
- Cleft lip/palate-ectodermal dysplasia syndrome
- Congenital ichthyosiform erythroderma
- Deafness-genital anomalies-metacarpal and metatarsal synostosis syndrome
- Deficiency in anterior pituitary function-variable immunodeficiency syndrome
- Epidermolysis bullosa simplex with anodontia/hypodontia
- Erythrokeratodermia variabilis
- Fibrodysplasia ossificans progressiva
- Flynn-Aird syndrome
- Giant cell arteritis
- Hereditary bullous dystrophy, macular type
- Hidrotic ectodermal dysplasia
- Hypocalcemic vitamin D-resistant rickets
- Incontinentia pigmenti
- Juvenile dermatomyositis
- Kerion celsi
- Kikuchi-Fujimoto disease
- Lamellar ichthyosis
- Mandibuloacral dysplasia
- Mandibuloacral dysplasia with type B lipodystrophy
- Neutral lipid storage disease with ichthyosis
- Oculocerebrocutaneous syndrome
- Pili torti
- Pili torti-onychodysplasia syndrome
- Polyendocrine-polyneuropathy syndrome
- Renpenning syndrome
- Schöpf-Schulz-Passarge syndrome
- Sézary syndrome
- SHORT syndrome
- Systemic lupus erythematosus
- Terminal osseous dysplasia-pigmentary defects syndrome
- Trichodysplasia-xeroderma syndrome
- Trichomegaly-retina pigmentary degeneration-dwarfism syndrome
- Zellweger-like syndrome without peroxisomal anomalies
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Tracking symptoms like this for someone? Eleplan keeps symptoms, diagnoses, medications and every specialist in one plan.
Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.