Rare diseases · Sign or symptom
Abnormal nail morphology
Abnormality of the nail
HP:0001597
What it means
Abnormal structure or appearance of the nail.
Abnormality of the fingernails and/or toenails.
In everyday care
Most people with this sign do not have a rare disease — it appears in common conditions far more often. These general reference pages cover the same topic:
Rare diseases that can present with this55
Very common80–99%
19- Acrodysostosis
- ADULT syndrome
- Autosomal dominant palmoplantar keratoderma and congenital alopecia
- Chronic mucocutaneous candidiasis
- Darier disease
- Ellis-Van Creveld syndrome
- FLOTCH syndrome
- Generalized pustular psoriasis
- Hidrotic ectodermal dysplasia, Christianson-Fourie type
- Huriez syndrome
- Hypodontia-dysplasia of nails syndrome
- Monilethrix
- Nail-patella syndrome
- Odontomicronychial dysplasia
- Otoonychoperoneal syndrome
- Progeroid syndrome, Petty type
- Reactive arthritis
- Severe generalized junctional epidermolysis bullosa
- Spondyloepimetaphyseal dysplasia, aggrecan type
Common30–79%
20- Acrodermatitis enteropathica
- Alkaptonuria
- Autosomal dominant hypocalcemia
- Autosomal dominant popliteal pterygium syndrome
- Autosomal recessive methemoglobinemia
- Autosomal semi-dominant severe lipodystrophic laminopathy
- Congenital ichthyosiform erythroderma
- Dermatoosteolysis, Kirghizian type
- Familial partial lipodystrophy, Dunnigan type
- Focal palmoplantar and gingival keratoderma
- Ichthyosis follicularis-alopecia-photophobia syndrome
- Intellectual disability, Wolff type
- Oculodentodigital dysplasia
- Papillon-Lefèvre syndrome
- Pili torti
- Pityriasis rubra pilaris
- Pycnodysostosis
- Split-foot malformation-mesoaxial polydactyly syndrome
- Striate palmoplantar keratoderma
- Tricho-dento-osseous syndrome
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions, and Orphanet separately records 1 disease where this sign is specifically absent. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Nail disease
Tracking symptoms like this for someone? Eleplan keeps symptoms, diagnoses, medications and every specialist in one plan.
Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.