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ORPHA:66529Disease
Also called Ampulla cardiomyopathy · Apical ballooning syndrome · Ballooning cardiomyopathy · Broken heart syndrome · Stress cardiomyopathy · Tako-Tsubo syndrome · Takotsubo cardiomyopathy · Takotsubo syndrome · Transient left ventricular apical ballooning syndrome
What it is
A rare cardiac disease characterized by acute occurrence of heart failure after an emotional or physical trigger; recovery of the wall motion abnormalities are observed within months. Symptoms are similar to acute coronary syndrome (ACS).
Key facts
- Prevalence
- 1-9 / 100 000 (annual incidence, France)
- Age of onset
- All ages
- Inheritance
- Unknown
- Classified as
- Disease
Prevalence figures describe populations, not individuals, and are often estimates from a single study. Where the figure is an incidence or a birth prevalence, it says so.
Signs and symptoms
Common30–79%
5Sometimes5–29%
16- Abnormal B-type natriuretic peptide level
- Angina pectoris
- Decreased QRS voltage
- Dilatation of the ventricular cavity
- Dyspnea
- Hypertension
- Hypotension
- Left ventricular apical dyskinesis
and 8 more in this range
Rare1–4%
11- Arrhythmia
- Atrial fibrillation
- Bradycardia
- Cardiogenic shock
- Mitral regurgitation
- Pulmonary edema
- Seizure
- Syncope
and 3 more in this range
These ranges are how often a sign appears across everyone diagnosed, not a prediction for one person — most people have some of these and not others. Orphanet also records findings that are specifically absent in this disease; those are in the data but not listed here.
ICD-10 codes
ICD-10 has no distinct code for most rare diseases, so many are filed under the nearest available one. A shared code identifies the group, not this disease — the ORPHAcode above is what identifies it.
Related health topics
Reached through the ICD-10 categories this disease is filed under, so these describe the broader group rather than this disease specifically.
Cross-references
Orphadata Science: Free access data from Orphanet. © INSERM 1999. Data version 2026-06-23. Available under CC BY 4.0. This is a reference, not medical advice.
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