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Start free with EleplanSerotonin syndrome
ORPHA:43116Disease
Also called Serotonergic syndrome · Serotonin storm · Serotonin toxicity · Serotonin toxidrome
What it is
A rare neurologic disease characterized by an excess of serotonin in the central nervous system, associated with the use of various agents, including selective serotonin reuptake inhibitors (SSRIs) and recreational stimulants.
Key facts
- Age of onset
- All ages
- Inheritance
- Not applicable
- Classified as
- Disease
Signs and symptoms
Common30–79%
11Sometimes5–29%
11- Abnormal saccadic eye movements
- Agitation
- Clonus
- Decreased vigilance
- Hyperhidrosis
- Hyperreflexia
- Hypertension
- Lactic acidosis
and 3 more in this range
Rare1–4%
11- Acute kidney injury
- Coma
- Delirium
- Disseminated intravascular coagulation
- Fever
- Hallucinations
- Hepatic failure
- Hypertonia
and 3 more in this range
These ranges are how often a sign appears across everyone diagnosed, not a prediction for one person — most people have some of these and not others. Orphanet also records findings that are specifically absent in this disease; those are in the data but not listed here.
ICD-10 codes
Related health topics
Reached through the ICD-10 categories this disease is filed under, so these describe the broader group rather than this disease specifically.
Cross-references
Orphadata Science: Free access data from Orphanet. © INSERM 1999. Data version 2026-06-23. Available under CC BY 4.0. This is a reference, not medical advice.
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