Rare diseases · Sign or symptom
Agitation
HP:0000713
What it means
A state of excessive motor activity that is associated with mental distress or a feeling of substantial unease or inner tension. Distinguished from restlessness by the increased level of emotional distress and negative intensity of the experience. Agitation has a significant level of physical activity that is typically threatening to the self or others.
Rare diseases that can present with this39
Very common80–99%
4Common30–79%
15- Acute liver failure
- Autosomal dominant hyperinsulinism due to Kir6.2 deficiency
- Autosomal dominant hyperinsulinism due to SUR1 deficiency
- Cocaine intoxication
- Familial gestational hyperthyroidism
- Familial hyperthyroidism due to mutations in TSH receptor
- Fragile X-associated tremor/ataxia syndrome
- FRAXE intellectual disability
- Huntington disease
- Hyperinsulinism due to HNF1A deficiency
- Hyperinsulinism due to UCP2 deficiency
- Idiopathic catatonia
- Kleine-Levin syndrome
- MEHMO syndrome
- SUNCT syndrome
Sometimes5–29%
18- 6-pyruvoyl-tetrahydropterin synthase deficiency
- Beta-ketothiolase deficiency
- Cerebrotendinous xanthomatosis
- Crimean-Congo hemorrhagic fever
- Developmental delay-facial dysmorphism syndrome due to MED13L deficiency
- Hemorrhagic fever-renal syndrome
- Hereditary late-onset Parkinson disease
- Hyperammonemia due to N-acetylglutamate synthase deficiency
and 10 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Psychomotor agitation
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.