Rare diseases · Sign or symptom
Restlessness
HP:0000711
What it means
A state of unease is characterized by diffuse motor activity or motion, which is subject to limited control, nonproductive, or disorganized behavior.
Rare diseases that can present with this19
Common30–79%
6Sometimes5–29%
12- 6-pyruvoyl-tetrahydropterin synthase deficiency
- Acute intermittent porphyria
- Amoebiasis due to free-living amoebae
- Developmental delay-facial dysmorphism syndrome due to MED13L deficiency
- Floating-Harbor syndrome
- HSD10 disease, infantile type
- Huntington disease-like 1
- Narcolepsy type 1
and 4 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Fidgetiness · Restiveness
Tracking symptoms like this for someone? Eleplan keeps symptoms, diagnoses, medications and every specialist in one plan.
Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.